_Abstract:_ This paper poses the following questions: What is pluralistic hegemony? What are its defining features? Can populism be seen to possess them? We draw on Laclau’s thought to examine whether antagonism and “the name of the leader” as an empty signifier are incompatible with pluralism. With reference to various different perspectives regarding the relationship between pluralism, hegemony and populism, we present our own particular understanding. Our conceptualization distances itself from the notion that pluralism involves an endless proliferation of difference (...) and the agonistic view that seeks to sublimate antagonism, and also from Laclau’s “the name of the leader” as an archetypal signifier of populism. Rather than the political frontier being the antithesis of pluralism, we see it as its precondition, with the empty signifier not representing a problem in itself, except when its name is pre-given. We perceive pluralism as being open to contingency, as a logic of the production and flow of differences. (shrink)

ABSTRACT The purpose of this paper is to examine critically Julian Savulescu's claim that people should select, of the possible children they could have, the one who is expected to have the best life, or at least as good a life as the others, based on the relevant, available genetic information, including information about non‐disease genes. I argue here that in defending this moral obligation, Savulescu has neglected several important issues such as access to selection technologies, disproportionate burdens on women, (...) difficulties in determining what is best, problems with aggregate effects of individual choices, and questions about social justice. Taking these matters into account would call such a moral requirement into serious question. (shrink)

ABSTRACT The purpose of this paper is to examine critically Julian Savulescu's claim that people should select, of the possible children they could have, the one who is expected to have the best life, or at least as good a life as the others, based on the relevant, available genetic information, including information about non‐disease genes. I argue here that in defending this moral obligation, Savulescu has neglected several important issues such as access to selection technologies, disproportionate burdens on women, (...) difficulties in determining what is best, problems with aggregate effects of individual choices, and questions about social justice. Taking these matters into account would call such a moral requirement into serious question. (shrink)

The lack of public support for climate change policies and refusals to vaccinate children are just two alarming illustrations of the impacts of dissent about scientific claims. Dissent can lead to confusion, false beliefs, and widespread public doubt about highly justified scientific evidence. Even more dangerously, it has begun to corrode the very authority of scientific consensus and knowledge. Deployed aggressively and to political ends, some dissent can intimidate scientists, stymie research, and lead both the public and policymakers to oppose (...) important public policies firmly rooted in science. -/- To criticize dissent is, however, a fraught exercise. Skepticism and fearless debate are key to the scientific process, making it both vital and incredibly difficult to characterize and identify dissent that is problematic in its approach and consequences. Indeed, as de Melo-Martín and Intemann show, the criteria commonly proposed as means of identifying inappropriate dissent are flawed and the strategies generally recommended to tackle such dissent are not only ineffective but could even make the situation worse. -/- The Fight Against Doubt proposes that progress on this front can best be achieved by enhancing the trustworthiness of the scientific community and by being more realistic about the limits of science when it comes to policymaking. It shows that a richer understanding of the context in which science operates is needed to disarm problematic dissent and those who deploy it. This, the authors argue, is the best way forward, rather than diagnosing the many instances of wrong-headed dissent. (shrink)

One of the key insights of Simone de Beauvoir’s The Second Sex is the idea that gender-based subordination is not just something done to women, but also something women do to themselves. This raises a question about ethical responsibility: if women are complicit, or actively implicated in their own oppression, are they at fault? Recent Beauvoir scholarship remains divided on this point. Here, I argue that Beauvoir did, in fact, ethically criticize many women for their complicity, as a sign of (...) what she called “bad faith”. I challenge recent accounts by Nancy Bauer and Manon Garcia, who both read Beauvoir as exonerating complicit women. According to this reading, women emerge as human “freedoms” within a social world where a “destiny” of inferiority is already prepared for them. Their self-subordination is then an inevitable product of acting in a patriarchal world. I argue, however, that this interpretation generates a crucial tension, leading Bauer and Garcia to call on women to stop being complicit, while also claiming they cannot avoid complicity. I propose instead a different interpretation, on which feminine complicity is often fueled by criticizable ethical attitudes that are far from inevitable. By revisiting Beauvoir’s notion of “bad faith”, I show that this account is compatible with recognizing the limitations imposed on women’s agency and I show that this feminist ethical criticism is itself an important part of a collective project of social transformation. (shrink)

Reprogenetic technologies, which combine the power of reproductive techniques with the tools of genetic science and technology, promise prospective parents a remarkable degree of control to pick and choose the likely characteristics of their offspring. Not only can they select embryos with or without particular genetically-related diseases and disabilities but also choose embryos with non-disease related traits such as sex. -/- Prominent authors such as Agar, Buchanan, DeGrazia, Green, Harris, Robertson, Savulescu, and Silver have flocked to the banner of reprogenetics. (...) For them, increased reproductive choice and reduced suffering through the elimination of genetic disease and disability are just the first step. They advocate use of these technologies to create beings who enjoy longer and healthier lives, possess greater intellectual capacities, and are capable of more refined emotional experiences. Indeed, Harris and Savulescu in particular take reprogenetic technologies to be so valuable to human beings that they have insisted that their use is not only morally permissible but morally required. -/- Rethinking Reprogenetics challenges this mainstream view with a contextualised, gender-attentive philosophical perspective. De Melo-Martín demonstrates that you do not have to be a Luddite, social conservative, or religious zealot to resist the siren song of reprogenetics. Pointing out the flawed nature of the arguments put forward by the technologies' proponents, Rethinking Reprogenetics reveals the problematic nature of the assumptions underpinning current evaluations of these technologies and offers a framework for a more critical and skeptical assessment. (shrink)

In recent years, online “involuntary celibate” or “incel” communities have been linked to various deadly attacks targeting women. Why do these men react to romantic rejection with not just disappointment, but murderous rage? Feminists have claimed this is because incels desire women as objects or, alternatively, because they feel entitled to women’s attention. I argue that both of these explanatory models are insufficient. They fail to account for incels’ distinctive ambivalence toward women—for their oscillation between obsessive desire and violent hatred. (...) I propose instead that what incels want is a Beauvoirian “Other.” For Beauvoir, when men conceive of women as Others, they represent them as simultaneously human subjects and embodiments of the natural world. Women function then as sui generis entities through which men can experience themselves as praiseworthy heroes, regardless of the quality of their actions. I go on to give an illustrative analysis of Elliot Rodger’s autobiographical manifesto, “My Twisted World.” I show how this Beauvoirian model sheds light on Rodger’s racist and classist attitudes and gives us a better understanding of his ambivalence toward women. It therefore constitutes a powerful and overlooked theoretical alternative to accounts centered on objectification and entitlement. (shrink)

When philosophers do not have a way out for choosing between the account they defend or a competing one, they usually appeal to theoretical virtues, such as simplicity, unity, fruitfulness, explanatory power, and so on. In this paper, my aim is to question the status of simplicity as a criterion for theory choice. My main arguments are that, first, it is hard to determine an objective metrics for evaluating simplicity, and second, we have no way to decide which one we (...) should prioritize: whether the ontological or the ideological variant of this theoretical virtue. In order to defend this stance, I will present the defenses of both ontological and ideological simplicity and then criticize each of them. I will also point out that the usual appeal metaphysicians make to scientific practice is not enough, given that the role of simplicity in science is not so clear and that philosophy in general has a very distinct nature as an endeavor. In the end, I will sketch a metaphilosophical pessimistic conclusion according to which not just metaphysics, but much of philosophy, is maybe doomed to be an endless effort of inconclusive arguments, since most of philosophical explanations appeal to theoretical virtues as a decisive factor in their disputes. (shrink)

The argument from inductive risk has been embraced by many as a successful account of the role of values in science that challenges the value-free ideal. We argue that it is not obvious that the argument from inductive risk actually undermines the value-free ideal. This is because the inductive risk argument endorses an assumption held by proponents of the value-free ideal: that contextual values never play an appropriate role in determining evidence. We show that challenging the value-free ideal ultimately requires (...) rejecting this assumption. (shrink)

Philosophers of science, particularly those working on science and values, often talk about the need for science to be socially responsible. However, what this means is not clear. In this paper, we review the contributions of philosophers of science to the debate over socially responsible science and explore the dimensions that a fruitful account of socially responsible science should address. Our review shows that offering a comprehensive account is difficult. We contend that broad calls for socially responsible science that fail (...) to attend to relevant dimensions are not the solution, as they preclude meaningful changes to research institutions and practices. We conclude that narrower, more explicit accounts are more likely to lead to substantive transformation. (shrink)

The use of genome embryo editing tools in reproduction is often touted as a way to ensure the birth of healthy and genetically related children. Many would agree that this is a worthy goal. The purpose of this paper is to argue that, if we are concerned with justice, accepting such goal as morally appropriate commits one to rejecting the development of embryo editing for reproductive purposes. This is so because safer and more effective means exist that can allow many (...) more prospective parents to achieve the same valued goal and that offer additional benefits. (shrink)

Although science is our most reliable producer of knowledge, it can also be used to create ignorance, unjustified doubt, and misinformation. In doing so, agnotological practices result not only in epistemic harms but also in social ones. A way to prevent or minimise such harms is to impede these ignorance-producing practices. In this paper, I explore various challenges to such a proposal. I first argue that reliably identifying agnotological practices in a way that permits the prevention of relevant harms is (...) more difficult than it might appear. I focus on an identifying criterion that many find apt for the task: bad faith motives. I then consider an objection—that reliable criteria are unnecessary to successfully address the concerns raised by agnotological strategies—and I show that it fails. I conclude by exploring other ways of conceptualising the problems attributed to agnotological practices. In particular, I challenge the focus on misinformation as the main problem of concern. (shrink)

Recently, some have proposed moral bioenhancement as a solution to the serious moral evils that humans face. Seemingly disillusioned with traditional methods of moral education, proponents of bioenhancement believe that we should pursue and apply biotechnological means to morally enhance human beings. Such proposal has generated a lively debate about the permissibility of moral bioenhancement. We argue here that such debate is specious. The claim that moral bioenhancement is a solution - whether permissible or not - to the serious moral (...) problems that affect human beings is based on several problematic framing assumptions. We evaluate here three of such assumptions: the first rests on a contested understanding of morality, the second consist in a mistaken conception of human moral problems, and the third relates to problematic presuppositions grounding the interpretation of existent scientific evidence presented to defend moral bioenhancement. Once these framing assumptions are identified and critically evaluated, it becomes clear that the moral bioenhancement debate is misguided. (shrink)

At the end of 2017, Kristen Roupenian’s short story, Cat Person, went viral. Published at the height of the #MeToo movement, it depicted a ‘toxic date’ and a disturbing sexual encounter between Margot, a college student, and Robert, an older man she meets at work. The story was widely viewed as a relatable denunciation of women’s powerlessness and routine victimization. In this paper, I push against this common reading. I propose an alternative feminist interpretation through the lens of Simone de (...) Beauvoir’s notion of narcissism: a form of alienation that consists in making oneself both the subject and the ultimate project of one’s life. Framing Margot as a narcissist casts her as engaging, not in subtly coerced, undesired sex, but rather in sex that is desired in a tragically alienated way. I argue that Beauvoir’s notion of narcissism is an important tool for feminists today – well beyond the interpretation of Cat Person. It presses us to see systematic subordination not just as something done to women, but also as something women do to themselves. This in turn highlights the neglected role of self-transformation as a key aspect of feminist political resistance. (shrink)

Recently, some have proposed moral bioenhancement as a solution to the serious moral evils that humans face. Seemingly disillusioned with traditional methods of moral education, proponents of bioenhancement believe that we should pursue and apply biotechnological means to morally enhance human beings. Such proposal has generated a lively debate about the permissibility of moral bioenhancement. We argue here that such debate is specious. The claim that moral bioenhancement is a solution – whether permissible or not – to the serious moral (...) problems that affect human beings is based on several problematic framing assumptions. We evaluate here three of such assumptions: the first rests on a contested understanding of morality, the second consist in a mistaken conception of human moral problems, and the third relates to problematic presuppositions grounding the interpretation of existent scientific evidence presented to defend moral bioenhancement. Once these framing assumptions are identified and critically evaluated, it becomes clear that the moral bioenhancement debate is misguided. (shrink)

Proponents of moral enhancement believe that we should pursue and apply biotechnological means to morally enhance human beings, as failing to do so is likely to lead to humanity's demise. Unsurprisingly, these proposals have generated a substantial amount of debate about the moral permissibility of using such interventions. Here I put aside concerns about the permissibility of moral enhancement and focus on the conceptual and evidentiary grounds for the moral enhancement project. I argue that such grounds are quite precarious.

Many have argued that allowing and encouraging public avenues for dissent and critical evaluation of scientific research is a necessary condition for promoting the objectivity of scientific communities and advancing scientific knowledge . The history of science reveals many cases where an existing scientific consensus was later shown to be wrong . Dissent plays a crucial role in uncovering potential problems and limitations of consensus views. Thus, many have argued that scientific communities ought to increase opportunities for dissenting views to (...) be heard and taken seriously. Such opportunities are necessary for both limiting the influence .. (shrink)

Recent advances in biotechnologies have led to speculations about enhancing human beings. Many of the moral arguments presented to defend human enhancement technologies have been limited to discussions of their risks and benefits. The author argues that in so far as ethical arguments focus primarily on risks and benefits of human enhancement technologies, these arguments will be insufficient to provide a robust defence of these technologies. This is so because the belief that an assessment of risks and benefits is a (...) sufficient ethical evaluation of these technologies incorrectly presupposes that risk assessments do not involve value judgements. Second, it presupposes a reductionist conception of ethics as merely a risk management instrument. Each of these assumptions separates ethical evaluation from discussion and appraisal of ends and means and thus leaves important—indeed, essential—ethical considerations out of view. Once these problematic assumptions are rejected, it becomes clear that an adequate defence of human enhancement technologies requires more than a simple balance of their risks and benefits. (shrink)

According to sparse modalism, the notion of essence can be analysed in terms of necessity and naturalness. In this paper, I develop and defend a version of sparse modalism that is equipped with a non-standard, relativized conception of naturalness. According to this conception, properties and relations can be natural to different degrees relative to different kinds of things, and relations can be natural to different degrees relative to different slots. I argue that this relativized version of sparse modalism can accommodate (...) various cases that the standard, non-relativized version can’t. The alternative version can accommodate cases where a relation is essential to a relatum but merely necessary to another, cases where a property is essential to an object but merely necessary to another, and cases where a less-than-perfectly natural property is essential to an object. (shrink)

Several feminist philosophers of science have argued that social and political values are compatible with, and may even enhance, scientific objectivity. A variety of normative recommendations have emerged regarding how to identify, manage, and critically evaluate social values in science. In particular, several feminist theorists have argued that scientific communities ought to: 1) include researchers with diverse experiences, interests, and values, with equal opportunity and authority to scrutinize research; 2) investigate or "study up" scientific phenomena from the perspectives, interests, and (...) conditions of marginalized stakeholders potentially affected by the research; and 3) make gender, ethnicity, class, and geographical location "visible," or use them as categories of analysis when appropriate. Yet, more work is needed to determine what exactly these recommendations would require, and the benefits they would yield, in specific research contexts. Using the recent development of the human papillomavirus (HPV) vaccines, we examine how these three feminist recommendations would have applied. We argue that these principles would have yielded several epistemic and social benefits in the HPV case, as well as in biomedical research more generally. That is, biomedical research guided by these principles would not only be epistemically superior, but also more socially responsible. (shrink)

Although surprising to some proponents of sex selection for non-medical reasons (Dahl 2005), a considerable amount of critical debate has been raised by this practice (Blyth, Frith, and Crawshaw 2008; Dawson and Trounson 1996; Dickens 2002; Harris 2005; Heyd 2003; Holm 2004; Macklin 2010; Malpani 2002; McDougall 2005; Purdy 2007; Seavilleklein and Sherwin 2007; Steinbock 2002; Strange and Chadwick 2010; Wilkinson 2008). While abortion or infanticide has long been used as means of sex selection, a new technology—preimplantation genetic diagnosis (PGD)—has (...) become a highly efficient, and arguably less controversial, way of ensuring the birth of a child of a particular sex. PGD, used in combination with in vitro .. (shrink)

Varro's De lingua Latina is a treasure trove of information. Of the originally twenty-five books, six have come down to us more or less complete. Among these, Books 5–7 give us many hundreds of etymologies, and Books 8–10 discuss the question whether Latin morphology is regular or not. What Varro rarely comments on is sociolinguistic variation. The sociolinguistic comments in Varro's work can almost be counted on one hand. For instance, in 5.162 Varro remarks that cenaculum, from cena ‘dinner’, means (...) ‘attic’ in Roman Latin, but that the original meaning was, as one might expect, ‘dining-room’, a meaning preserved in the non-Roman dialects of Latium, Falerii and Corduba in Spain; the meaning also lives on in religious uses in Lanuvium. In 7.96, Varro tells us that some words are pronounced with -ae- by some, but with -ē- by others. We know that non-Roman varieties of Latin monophthongized -ae- earlier than the Roman dialect did. Varro mentions pairs like scaena / scēna ‘stage’, a loan from Greek σκηνή, which shows that -ae- is hypercorrect here. Interestingly, only in one such pair is the variant with -ē- ascribed to country people, in the name Maesius / Mēsius, and this is indeed the only pair where the diphthong -ae- is original rather than the result of hypercorrection. (shrink)

Despite increasing recognition of the ways in which ethical and social values play a role in science (Kitcher 2001; Longino 1990, 2002), scientists are often still reluctant to acknowledge or discuss ethical and social values at stake in their research. Even when research is closely connected to developing public policy, it is generally held that it should be empirical data, and not the values of scientists, that inform policy. According to this view, scientists need not, and should not, endorse non-epistemic (...) values related to their research, as doing so may bias their assessment of what the evidence is. As a result, debates over science-based policy tend to be construed solely as empirical discussions to be .. (shrink)

This article focuses on the relationship between ecological citizenship and the green state and asks whether it is a productive one. First, I examine the political system of an ideal ecological state to assess how it could encourage ecological citizenship. Then, I turn my attention to how eco-states might emerge and be sustained, and the obstacles they may encounter. I show that the green state has a strong potential to develop ecological citizenship, albeit with a rather narrow focus on its (...) deliberative dimension. However, my main point is that this potential may not be fully realised because the green state is grounded on a postliberal ecological democracy and an ecologically modernised economy. Since the green state cannot avoid the problems arising from the nexus between liberal democracy and capitalism, I claim that it is not the most appropriate locus for the cultivation of ecological citizenship. (shrink)

Discussions about whether new biomedical technologies threaten or violate human dignity are now common. Indeed, appeals to human dignity have played a central role in national and international debates about whether to allow particular kinds of biomedical investigations. The focus of this paper is on chimera research. I argue here that both those who claim that particular types of human-nonhuman chimera research threaten human dignity and those who argue that such threat does not exist fail to make their case. I (...) first introduce some of the arguments that have been offered supporting the claim that the creation of certain sorts of chimeras threatens or violates human dignity. I next present opponents' assessments of such arguments. Finally I critically analyze both the critics' and the supporters' claims about whether chimera research threatens human dignity. (shrink)

O que pode dizer um homem que fez o voto de se dedicar a Deus a outro que está plenamente convencido de Deus não existe? O que pode ouvir um crente de um ateu? O que um ateu pode aprender? São questões assim que guiaram o encontro entre o padre Fábio de Melo e o historiador Leandro Karnal e resultaram neste livro. Um debate rico e respeitoso entre um cético e um católico que oferece uma referência importante aos brasileiros (...) crentes e não crentes. Com coragem para provocar um ao outro e humildade para aceitar os argumentos, os autores discutiram pontos fundamentais, como se o mundo é melhor ou pior sem Deus e se a religião ajuda ou atrapalha. Questionaram o quanto a fé faz falta e discutiram as esperanças, os medos e a morte no horizonte de quem crê e quem não crê. Crer ou não crer é o resultado de muitas horas de conversa entre um dos padres mais amados do país com um dos mais populares historiadores. Uma obra que irá agradar e enriquecer milhões de leitores. (shrink)

Resumo: Este artigo possui o propósito de colocar à prova a interpretação heideggeriana acerca das noções nietzschianas de vontade de potência e eterno retorno do mesmo. Para levar a cabo o referido objetivo, de início, apresentaremos o argumento desenvolvido por Heidegger nas suas preleções e textos sobre Nietzsche, editadas e publicadas em dois volumes, no ano de 1961. Num segundo momento, examinaremos, em Nietzsche: sua filosofia dos antagonismos e os antagonismos de sua filosofia, a resposta que Müller-Lauter ofereceu à crítica (...) de Heidegger. Por ocasião deste exame, tentaremos salientar que haveria certa insuficiência na réplica deste comentador. Por fim, iremos recorrer aos textos do próprio Nietzsche para tentar promover uma confrontação com a interpretação do Filósofo da Floresta Negra.: This article has the purpose to challenge the Heideggerian interpretation of Nietzsche’s notions of will to power and eternal recurrence. To carry out this objective, we will first present the argument developed by Heidegger in his lectures and texts on Nietzsche, edited and published in two volumes, in 1961. In a second moment, we will examine, in Nietzsche: his philosophy of antagonisms and the antagonisms of his philosophy, the answer that Müller-Lauter offered to Heidegger’s criticism. On the occasion of this examination, we will try to point out that there would be a certain insufficiency in this commenter’s reply. Finally, we will resort to Nietzsche’s own texts to try to promote a confrontation with the Black Forest Philosopher’s interpretation. (shrink)

1. Introdução problematizante / Daniel Melo Tal como aludido no artigo anterior, o painel «As editoras e o seu património: preservar, disponibilizar e divulgar como medidas urgentes» tornou-se um marco na área dos estudos sobre a edição e sobre património por causa do seu carácter inovador – nunca até então se tinha feito um encontro exclusivamente destinado a debater a questão da preservação, valorização e disponibilização dos arquivos definitivos das editoras portuguesas. Além deste pionei...

Recent times have seen increasing interest in conversational assistants (e.g., Amazon Alexa) designed to help users in their daily tasks. In military settings, it is critical to design assistants that are, simultaneously, helpful and able to minimize the user’s cognitive load. Here we show that embodiment plays a key role in achieving that goal. We present an experiment where participants engaged in the desert survival task in augmented reality. Participants were paired with a voice assistant, an embodied assistant, or no (...) assistant. The assistants made suggestions verbally throughout the task, whereas the embodied assistant further used gestures and emotion to communicate with the user. Our results indicate that both assistant conditions led to higher performance over the no assistant condition, but the embodied assistant achieved this with less cognitive burden on the decision maker than the non-embodied assistant. We discuss implications for the design of intelligent collaborative systems for the warfighter. (shrink)

In most western countries, there is a 'human organ shortage' with waiting lists for the performance of transplantation. In a recent report of the UNOS Ethics Committee it is stated that there are approximately 31,000 potential recipients on waiting lists, but only one fourth of potential donors give their specific consent. Xenotransplantation--defined as the transplantation of animal cells, tissues or organs into human beings--is associated with particular ethical dilemmas, namely the problems of efficiency and safety of this medical procedure. The (...) objective of this study is to analyse the ethical dilemmas in xenotransplantation with the background of a personal view of moral life. Also, xenotransplantation will be evaluated as far as the legal regulation of transplantation is concerned. In particular, we will consider patients rights in accordance with existing laws on organ and tissue transplantation, animal research and clinical trials. (shrink)

The aim of this paper is to show that critics of biological explanations of human nature may be granting too much to those who propose such explanations when they argue that the truth of genetic determinism implies an end to critical evaluation and reform of our social institutions. This is the case because when we argue that biological determinism exempts us from social critique we are erroneously presupposing that our social values, practices, and institutions have nothing to do with what (...) makes biological explanations troublesome. My argument is that what constitutes a problem for those who are concerned with social justice is not the fact that particular behaviours may be genetically determined, but the fact that our value system and social institutions create the conditions that make such behaviours problematic. Thus, I will argue that even if genetic determinism were correct, the requirement of assessing and transforming our social practices and institutions would be far from superfluous. Biology is rarely destiny for human beings and the institutions they create. (shrink)

The purpose of this paper is to show that a decontextualized approach to ethical issues is not just unhelpful for the decision making process of real, situated human beings, but dangerous. This is so, because by neglecting the context in which people make moral decisions we run the risk of reinforcing or furthering injustices against already disadvantaged groups. To show this, I evaluate three moral obligations that our ability to obtain genetic information has made salient: the duty to obtain genetic (...) information about ourselves, the obligation to inform family members about genetic risks and the duty not to reproduce when we know that there is a high risk of transmitting a serious disease or defect. I will argue here that in ignoring the context in which these moral obligations are put into practice, and in particular the situation of women in our society, those who defend these moral duties might be furthering injustices against women. (shrink)

In most western countries, there is a ‘human organ shortage’ with waiting lists for the performance of transplantation. In a recent report of the UNOS Ethics Committee it is stated that there are approximately 31,000 potential recipients on waiting lists, but only one fourth of potential donors gave their specific consent.Xenotransplantation – defined as the transplantation of animal cells, tissues or organs into human beings – is associated with particular ethical dilemmas, namely the problems of efficiency and safety of this (...) medical procedure. The objective of this study is to analyse the ethical dilemmas in xenotransplantation with the background of a personal view of moral life. Also, xenotransplantation will be evaluated as far as the legal regulation of transplantation is concerned. In particular, we will consider patients rights in accordance with existing laws on organ and tissue transplantation, animal research and clinical trials. (shrink)

A significant amount of scientific evidence shows that childhood vaccination constitutes one of the most successful and cost-effective public health interventions of the last century. It has saved millions of lives. Nonetheless, many parents are reluctant or outright hostile to having their children vaccinated. Similarly, in spite of the fact that vaccines against SARS-CoV-2, the virus that causes COVID-19, are highly effective in protecting people against death and serious illness, about a third of adults in the United States are still (...) unvaccinated as of July 2022. What leads people to be skeptical of vaccines or to refuse them altogether?The dominant narrative answering this... (shrink)

Este artigo apresenta o mapeamento das possibilidades de pesquisa no âmbito da Ciência da Informação (CI) que tratam sobre o conceito de Privacy by Design (PbD). Se busca responder como a CI e os usos da teoria do PbD podem influenciar no alcance de maior privacidade aos usuários de sistemas de informação desde a concepção de produtos científicos até a pesquisa aplicada. Para responder esta pergunta, foram analisados 202 artigos, que balizaram a composição do mapa de possibilidades de pesquisa. O (...) mapeamento abrange temas como o controle e o acesso aos dados, privacidade como um bem social e a visão de que a privacidade toma forma de acordo com as tecnologias. Foram problematizados os aspectos éticos da privacidade no ambiente tecnológico e contextualizada a presença do conceito de PbD nas legislações de proteção de dados. Conclui-se que este estudo contribui ao reunir proposições para o ponto de partida na busca por pesquisas científicas transdisciplinares em CI e privacidade, que os profissionais de CI podem estar envolvidos na observância da privacidade em todas as camadas de negócio no desenvolvimento de sistemas, e que a área pode contribuir com os debates relacionados ao PbD em razão da privacidade ser bem social fundamental. (shrink)

Designer Biology: The Ethics of Intensively Engineering Biological and Ecological Systems consists of thirteen chapters that address the ethical issues raised by technological intervention and design across a broad range of biological and ecological systems. Among the technologies addressed are geoengineering, human enhancement, sex selection, genetic modification, and synthetic biology.

I discuss the role of beauty in physics. Physicists are sometimes described as platonists for their conviction that the fundamental laws are elegant and aesthetic arguments represent an important epistemic tool. After a review of the ideas of Plato and some of the leading figures of modern physics, which suggest that this is indeed the case, I present a list of current aesthetic criteria. I focus on symmetry and unity and demonstrate their increasing relevance in an array of experimentally verified (...) theories. I also deal with an open issue of naturalness as the third criterion. The laws of nature appear increasingly beautiful as we uncover them, and it is important to see if the trend continues in the future. (shrink)

The growing commercialization of science has raised concerns about financial conflicts of interest (COIs). Evidence suggests that such conflicts threaten the integrity of research and the well-being of research participants. Trying to minimize these negative effects, federal agencies, academic institutions, and publishers have developed conflict-of-interest policies. Among such policies, recommendations or requirements to disclose financial COIs to potential research participants and patients have become commonplace. Here, I argue that disclosing conflicts of interest to potential research participants fails to achieve the (...) weighty moral goals that presumably ground such policies. This is so either because disclosure is simply a wrong means for achieving some of the goals in question or because, although disclosure could be an appropriate means for some of those goals, the way in which it is implemented prevents fulfillment of the desirable moral aim. (shrink)

In “Human germline genome editing: On the nature of our reasons to genome edit,” Robert Sparrow (2022) presents a central claim and a secondary one. The central claim is that, for the foreseeable f...

Biobanks are important resources for improving public health and individual care. Some legal frameworks can be more or less conducive to advancing the potential benefits of biobanks. The purpose of this article is to assess biobanking legislation and practices in Spain to determine how well they fare in such a regard. We focus here on some of the primary ethical values that ground relevant legislation and that we believe are consistent with promoting biobanking benefits: the value of scientific research; efficient (...) use of scarce resources; and respect for the dignity of donors. We argue that although Spanish regulations advance these values in important ways, they also have provisions that undermine them and thus risk limiting the potential benefits of biobanks. We offer some suggestions for improvement. (shrink)

Recent discussion on the need to reassess research ethics standards has called into question familiar concepts such as equipoise, coercion, undue inducement, and the protection of vulnerable subjects. Reassessment of these concepts can be useful for a variety of reasons. It can eliminate conceptual murkiness, can assist in the proposal of regulations to better protect human subjects, and can elucidate ethical concerns. In this essay, I call attention here to a different, and often neglected, reason why reassessment of research ethics (...) concepts can be helpful. It can undermine the all-too-common practice of taking as a given the social and political conditions in which biomedical research takes place and can encourage the inclusion of broader questions about social justice, human flourishing, or about the importance of taking into account the social determinants of health and disease. I will focus on some recent attempts to reevaluate the concept of vulnerability in research ethics. I will argue that such attempts, by calling attention to the characteristics that can render participants vulnerable, can promote, rather than discourage, moral reflection about social and global justice concerns among bioethicists, policy makers, investigators, and members of Institutional Review Boards. (shrink)

Aldehyde dehydrogenase 2 (ALDH2) deficiency constitutes one of the most common hereditary enzyme deficiencies, affecting 35% to 40% of East Asians and 8% of the world population. It causes the well-known Asian Alcohol Flush Syndrome, characterized by facial flushing, palpitation, tachycardia, nausea, and other unpleasant feelings when alcohol is consumed. It is also associated with a marked increase in the risk of a variety of serious disorders, including esophageal cancer and osteoporosis. Our recent studies with murine models have demonstrated that (...) a one-time administration of an adeno-associated virus (AAV) gene transfer vector expressing the human ALDH2 coding sequence (AAVrh.10hALDH2) will correct the deficiency state and prevent alcohol-induced abnormalities of the esophagus and bone. If successful in humans, such strategy would reduce the increased risk-associated disorders such as esophageal cancer and osteoporosis, but also prevent the Asian Alcohol Flush Syndrome. This treatment thus raises ethical concerns: although it would potentially prevent fatal disease, it could also allow affected individuals to drink alcohol without suffering the Asian Alcohol Flush Syndrome and, hence, potentially enable personal destructive behavior. Here we explore the ethical arguments against the development of a gene therapy for ALDH2 deficiency and we find them wanting. We contend that development of such treatments is ethically appropriate and should be part and parcel of the solutions offered against the condition. (shrink)

I argue here that critics of biological explanations of human nature are mistaken when they maintain that the truth of genetic determinism implies the end of critical evaluation and reform of our social institutions. Such a claim erroneously presupposes that our social values, practices, and institutions have nothing to do with what makes biological explanations troublesome. What constitutes a problem for those who are concerned with social justice is not the fact that particular behaviors might be genetically determined, but the (...) fact that our value system and social institutions create the conditions that make such behaviors problematic. (shrink)

The commercialization of academic science has come to be understood as economically desirable for institutions, individual researchers, and the public. Not surprisingly, commercial activity, particularly that which results from patenting, appears to be producing changes in the standards used to evaluate scientists’ performance and contributions. In this context, concerns about a gender gap in patenting activity have arisen and some have argued for the need to encourage women to seek more patents. They believe that because academic advancement is mainly dependent (...) on productivity (Stuart and Ding in American Journal of Sociology 112:97–144, 2006 ; Azoulay et al. in Journal of Economic Behavior & Organization 63:599–623, 2007 ), differences in research output have the power to negatively impact women’s careers. Moreover, in the case of patenting activity, they claim that the gender gap also has the potential to negatively affect society. This is so because scientific and technological advancement and innovation play a crucial role in contemporary societies. Thus, women’s more limited involvement in the commercialization of science and technology can also be detrimental to innovation itself. Nevertheless, calls to encourage women to patent on grounds that such activity is likely to play a significant role in the betterment of both women’s careers and society seem to be based on two problematic assumptions: (1) that the methods to determine women’s productivity in patenting activities are an appropriate way to measure their research efforts and the impact of their work, and (2) that patenting, particularly in academia, benefits society. The purpose of this paper is to call into question these two assumptions. (shrink)

O artigo tem como foco o caso da Mineradora Belo Sun e busca associar a discussão de ética nas corporações e o impacto do negócio em espaços amazônicos tendo por escopo evidenciar o desrespeito das companhias quanto às regulações internas que asseguram direitos humanos de populações tradicionais que vivem no entorno do território afetado. Deve-se prioritariamente reconhecer como consequência as violações de direitos humanos que são impostas aos grupos impactados pelos grandes empreendimentos que capturam os agentes públicos decisores dos processos (...) de licenciamento, beneficiando-se da ausência da consolidação normativa socioambiental. (shrink)

Leibniz’s De incerti aestimatione, which contains his solution to the division problem, has not received much attention, let alone much appreciation. This is surprising because it is in this work that the definition of probability in terms of equally possible cases appears for the first time. The division problem is used to establish and test probability theory; it can be stated as follows: if two players agree to play a game in which one has to win a certain number of (...) rounds in order to win the pool, but if they break the game off before either of them has won the required number of rounds, how should the pool be distributed?Our article has two aims: it provides the readers with the first published English translation of De incerti aestimatione, and it also gives them a brief commentary that explains Leibniz’s philosophical and mathematical concepts necessary in order to understand this work. The translation is as literal as possible throughout; it shows how Leibniz struggled at times to find a solution to the division problem and how he approached it from different angles. The commentary discusses Leibniz’s views on four key concepts: fairness, hope, authority and possibility. The commentary then outlines how Leibniz attempted to solve the problem of division. (shrink)

This article is part of the research project ‘Representação midiática da violação de direitos e da violência contra pessoas em situação de rua no jornalismo on-line’, associated with Red Latinoamericana de Análisis Crítico del Discurso de la Extrema Pobreza, and focuses upon the ways in which electronic news media represent homeless people in Brazil. The focus is a pair of texts, related through internal hyperlinks, about the controversy concerning the installation of a social center in a middle-class neighborhood in central (...) Sao Paulo. The texts are analyzed on the theoretical basis of critical discourse analysis and considering the following analytical categories: metaphor, representation of social actors and intertextuality. Analyses show a scenario of ‘invasion by unwelcome people’, who are not perceived as rights holders, but as a threat to the rights of others. (shrink)

Anonymous gamete donation continues to be practised in most jurisdictions around the world, but this practice has come under increased scrutiny. Thus, several countries now mandate that donors be identifiable to their genetic offspring. Critics contend that anonymous gamete donation harms the interests of donor-conceived individuals and that protection of these interests calls for legal prohibition of anonymous donations. Among the vital interests that critics claim are thwarted by anonymous donation are an interest in having a strong family relationship, health (...) interests, and an interest in forming a healthy identity. This article discusses each of these interests and examines what they could involve. The legislation in two countries is considered: Spain, which mandates anonymous gamete donation, and the UK, which prohibits such practice, to assess how these different legislations might or might not protect these vital interests. (shrink)

Are the ideas of democracy and isonomy an absolute achievement of civilization, or just a tuning moment in a complex system of metamorphosis? Is this something universal or an aesthetic approach? Could our concept of art, in its deepest sense, be responsible for democracy? Or, could our concept of democracy exist because of art? This paper is a reflection on these questions. Normally, a scientific text should give answers but would this principle be universal? Inside our planetary metamorphosis all values (...) are changing as always but now at high speed. High speed gives us both the sensation of confusion, which was typical in other historical moments, as when Carmina Burana was elaborated in the Middle Ages, and the possibility to take a step back and have, in the eye of the cyclone, dynamic elements showing us change in process. In this paper, democracy and isonomy are taken as the content of a path towards civilization, in a new environment. (shrink)

We focus here on high-risk pediatric research with the prospect of direct benefit and point out some aspects that have raised significant debate. In particular, we call attention to disagreements related to two essential aspects of this type of research: (i) determining what constitutes a “prospect of direct benefit” in phase I trials that involve gene transfer technologies and (ii) assessing when in these trials the risk is justified by the anticipated benefit to the participant children. Although much of our (...) discussion is applicable to other types of high-risk pediatric trials, as an example of the dilemma this type of research poses we use pediatric trials that involve gene transfer technologies. We focus on clinical trials for late infantile neuronal ceroid lipofuscinosis (LINCL). Exploring the ethical implications of some of these disagreements might identify resources for determining how best to deal with the ethical concerns at stake in high-risk pediatric research. We thus offer some recommendations for responding to these concerns. (shrink)